McDowell describes the health of Kentucky volunteers under Governor Shelby and conditions on the campaign Harrison led against the British and Indians in Canada. He tells of the sickness and fever that has afflicted many men of the militia, and that several had died from the fever.
In this letter, McDowell criticizes Thomas Jefferson's policies and the direction of the United States under his leadership. He expresses fear that James Madison is following in Jefferson's footsteps.
In a letter dated 18 April 1792, McDowell mentions that the Kentucky Constitutional Convention has been meeting for the past two weeks framing the constitution for Kentucky and will finish the next day. McDowell thinks it to be "a tolerable good constitution." Kentucky became a state on 1 June 1792.