William Clark writes his brother Edmund Clark from St. Louis, Missouri, reporting on his current situation with his investment in the St. Louis Missouri Fur Company, and the furs he can and will send to people in Kentucky. He reports on American Indian affairs and general unrest in the region.
Clark writes his brother Jonathan from St. Louis informing him he has invested in the St. Louis Missouri Fur Company, is acting as an agent for the government's Native American trade factory system, and the trouble he is having with several of his enslaved persons and the punishment he is meting out. Julia requests seeds be sent to her because the rats have eaten all of hers. He keeps no copies of the letters he writes to him.
Clark writes his brother Jonathan from St. Louis discussing his frustrations with his enslaved African Americans York and Scipio. He reports on conditions in St. Louis, various individuals, and investments in lead mining and saltmaking in the region. Reports that Meriwether Lewis was installed as master of the local Masonic lodge.