Clark writes his brother Edmund from St. Louis reporting general news regarding the town and some of its inhabitants. He comments on the status of their nephews Benjamin O'Fallon, there with him in St. Louis, and his brother, John O'Fallon, in school in Lexington, Kentucky. He updates Edmund regarding the status of their interest in the St. Louis Missouri Fur Company and their planned mercantile business venture, and on Native American affairs both up the Missouri and the Mississippi.
William Clark writes to his brother Jonathan from St. Louis about his business affairs and their prospects. Refers him to John Luttig, his store manager who delivered this letter, for more details.
Clark writes his brother Jonathan from St. Louis about the land he wants to sell in Clark County, Indiana, and the state of his finances involving his mercantile pursuits and land. Mentions the whereabouts and health of various Clark family members, including M. Lewis who is sick with worms.
William Clark writes to Edmund Clark and John Hite Clark in their capacity as Louisville merchants, listing aticles for the Indian trade he wants for his store.