Clark writes his brother Jonathan from St. Louis regarding plans to travel east for a visit in the fall and their likely route. He reports how Julia and Lewis are doing, including Lewis being vaccinated with the cowpox and his reaction to being bathed. Sends regrets of George Rogers Clark's situation and hopes he will continue to recover. Talks of York's return to St. Louis from Kentucky and his continued bad attitude, punishment, and possible plans regarding him, and an enslaved woman Priscilla giving birth to a stillborn child and her little boy getting accidently scalded. He provides an update on the most recent news regarding Native American affairs and possible hostilities.
Clark writes his brother Jonathan from St. Louis regarding his enslaved man York, the St. Louis Missouri Fur Company, furs and peltries belonging to the government as part of the Indian trade factory system, and the route he might take in the fall eastward to Kentucky and Virginia.