Clark writes his brother Edmund from St. Louis reporting general news regarding the town and some of its inhabitants. He comments on the status of their nephews Benjamin O'Fallon, there with him in St. Louis, and his brother, John O'Fallon, in school in Lexington, Kentucky. He updates Edmund regarding the status of their interest in the St. Louis Missouri Fur Company and their planned mercantile business venture, and on Native American affairs both up the Missouri and the Mississippi.